Solid State Science and Technology, Vol. 19, No 1 (2011) 40-55
DEGRADATION AND DRUG RELEASE STUDIES OF COPOLYMER OF (1,3-
BIS(P-CARBOXYPHENOXY)PROPANE (CPP) AND SEBACIC ACID (SA)
LOADED WITH CIS PLATIN
M. Yusuf, F.S. Abdul Rahman, N.A. Johan, S.A. Abu Bakar and K. Noorsal*
Advanced Materials Research Centre (AMREC), SIRIM Berhad,
Lot 34, Jalan Hi-Tech 2/3, Kulim Hi-Tech Park, 09000 Kulim, Kedah, Malaysia
*Corresponding Author: email@example.com
The degradation and drug release studies of poly((1,3-bis(p-carboxyphenoxy))propaneco-
sebasic acid) loaded with cis platin are studied through various means. The drug
loaded samples were first prepared from compression molding technique and degraded
in 0.01M phosphate buffer saline at 37°C with pH of 7.4 at predetermined time.
Interaction of drug and the polymer was monitored through FTIR and DSC. The
influence of the drug to the degradation behaviour of the copolymer was detected
through mass loss and water uptake and also pH changes. Variable Pressure Scanning
Electron (VPSEM) was used in studying of the effect of degradation to the surface
topography of the samples. The drug release profile is monitored through the U.V.
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