Solid State Science and Technology, Vol. 19, No 1 (2011) 40-55

ISSN 0128-7389

40

 

DEGRADATION AND DRUG RELEASE STUDIES OF COPOLYMER OF (1,3-

BIS(P-CARBOXYPHENOXY)PROPANE (CPP) AND SEBACIC ACID (SA)

LOADED WITH CIS PLATIN

 

M. Yusuf, F.S. Abdul Rahman, N.A. Johan, S.A. Abu Bakar and K. Noorsal*

Advanced Materials Research Centre (AMREC), SIRIM Berhad,

Lot 34, Jalan Hi-Tech 2/3, Kulim Hi-Tech Park, 09000 Kulim, Kedah, Malaysia

*Corresponding Author: kartini@sirim.my

 

ABSTRACT

The degradation and drug release studies of poly((1,3-bis(p-carboxyphenoxy))propaneco-

sebasic acid) loaded with cis platin are studied through various means. The drug

loaded samples were first prepared from compression molding technique and degraded

in 0.01M phosphate buffer saline at 37°C with pH of 7.4 at predetermined time.

Interaction of drug and the polymer was monitored through FTIR and DSC. The

influence of the drug to the degradation behaviour of the copolymer was detected

through mass loss and water uptake and also pH changes. Variable Pressure Scanning

Electron (VPSEM) was used in studying of the effect of degradation to the surface

topography of the samples. The drug release profile is monitored through the U.V.

spectroscopy work.

 

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